Senior (Principal) Scientist – Molecular Biology and NGS, Personalized TCR Discovery

Senior (Principal) Scientist – Molecular Biology and NGS, Personalized TCR Discovery

Amsterdam

Neogene Therapeutics is a pre-clinical stage biotechnology company aiming to change the paradigm of treatment for solid cancers. Our mission is to provide cancer patients with T cell therapies targeting mutated proteins called neo-antigens, which are present on cancer cells as a consequence of DNA mutations. Neogene is developing novel technologies to enable the engineering of ‘designer T cells’ with neo-antigen specificities that display an optimized ability to seek and destroy cancer cells.

We are seeking a highly motivated individual to join our personalized TCR discovery team in Amsterdam as a Senior Scientist – Molecular Biology and NGS. The personalized TCR discovery team is responsible for isolating neo-antigen specific TCRs from a cancer patient’s tumor biopsy & characterizing these tumor-derived TCRs. Following isolation and characterization, neo-antigen specific TCRs are selected for the clinical manufacture of a fully personalized multi-specificity neo-antigen specific TCR engineered T cell therapy product that is used to treat the cancer patient. Reporting to the Head of the personalized TCR discovery team, the individual will assume responsibility for supervising a team of scientists and research associates performing experiments to isolate and characterize patient-derived neo-antigen specific TCRs for clinical use.

Responsibilities include, but are not limited to:

  • Supervise a team of research associates performing experiments to isolate patient-derived neo-antigen specific TCRs in a manner compliant with standards set out by relevant accredited agencies.
  • Drafting data reports and presentations to inform the selection of personalized TCRs for clinical use.
  • Serve as a subject matter expert for methods utilized for TCR discovery (e.g. molecular biology techniques, NGS technologies) & collaborate with the research team to support the identification, validation and implementation of process step improvements.
  • Drafting and reviewing of protocols, SOPs, batch records, technical reports and regulatory documents to support clinical development
  • Playing a key role in an integrated cross-functional team
  • Mentor and develop more junior staff
  • Other duties as assigned.

Requirements:

  • PhD with at least 3 year of relevant work experience in Molecular Biology and using NGS technologies. Experience of or an affinity for working in a GLP or GMP environment. Industry experience is a plus. Candidates with relevant experience may be eligible for a position as a Principal Scientist (at the company’s discretion).
  • Deep knowledge and experience with molecular biology techniques and next generation sequencing technologies (e.g. Illumina and ONT platforms)
  • Candidates with experience of or an affinity for T cell Immunology and/or genetic screening approaches is a strong plus.
  • Preference for candidate with experience of drafting and reviewing documentation to support clinical development
  • Preference for candidates with experience of working within a formal quality management system.
  • Experience of working in a cGMP or ISO 13485 production environment is a plus
  • Excellent organizational skills, with a preference for a candidate with experience of supervising more junior research staff
  • Comfortable with electronic document management systems and authoring tools
  • A strong sense of urgency with regards to work duties and the ability to deliver results based on challenging timelines.
  • Strong verbal and written communication skills and the ability to communicate results to a diverse cross-functional audience.
  • Comfortable in a fast-paced growing company environment and able to adjust workload based upon changing priorities.
  • We are seeking a person who will lead by example and is a self-motivated team player with strong interpersonal skills.

We offer the opportunity to join a highly dynamic biotech start-up. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide an exciting opportunity for your career.

If you are interested please submit your electronic application including cover letter and CV to careers@neogene.com

No recruiters. No phone calls.