(Senior) Scientist Synthetic T Cell Biology

Amsterdam

Neogene Therapeutics is a pre-clinical stage biotechnology company pioneering development of next-generation, fully personalized engineered T cells therapies for a broad spectrum of cancers. The Company’s engineered T cells target tumor neo-antigens, mutated proteins found in cancer cells due to cancer-associated DNA mutations, that render tumor cells vulnerable to detection by T cells. Neogene’s proprietary technology platform aims to identify TCR genes with specificity for neo-antigens from a tumor biopsy. Since every cancer expresses a unique set of neo-antigens, Neogene’s novel approach delivers a tailored set of TCR genes for each individual patient. These TCR genes are engineered into patient-derived T cells directing them towards neo-antigens in tumor cells, thereby providing a fully personalized engineered T cell therapy for cancer.

For our R&D department in Amsterdam, we are seeking a highly motivated individual to join our T cell engineering research team as a (Senior) Scientist. The individual will recognize and embrace the power of Synthetic Biology and use it to enhance the potency and clinical efficacy of neo-antigen–based T cell therapies.

Responsibilities include, but are not limited to:

Designing and performing experimental studies in the area of synthetic T cell biology, with a strong focus on the engineering of novel input/output circuits to enhance T cell function.
Driving innovation of Neogene’s pipeline, thereby paving the way for the next generation of T cell therapies.
Collaborating with the broader R&D team and supervising research associates and internship students.
Presenting obtained results in internal work discussions.
Keeping up to date with scientific literature, and proactively seeking out and reporting on relevant developments in the field.
Building and maintaining relationships with outside parties to expand Neogene’s research capabilities.
Documenting experimental results in electronic laboratory journal and databases.
Other duties as assigned.

Requirements:

PhD in Biomedical Sciences or a related field. Candidates with at least 5 years of relevant experience post PhD may be eligible for a position as Senior Scientist (at the company’s discretion).
A proven track-record in the field of Immunology and/or Synthetic Biology with seminal scientific contributions as exemplified by high-impact publications, patent applications, fellowships/grants and awards.
First-hand experience with aseptic cell culture, viral and non-viral genetic engineering (e.g. CRISPR), and multi-color flow cytometry is essential.
Additional training in the area of primary immune cell culture, genetic screening (vector design/construction and next-generation sequencing), and flow cytometry-based cell sorting is a plus.
Excellent organizational skills, a strong sense of urgency with regards to work duties and the ability to deliver results based on challenging timelines.
Strong verbal and written communication skills in English.
We are seeking a person who will lead by example and is a self-motivated team player with strong interpersonal skills.
Candidates must be authorized to work in The Netherlands.

We offer the opportunity to join a highly dynamic growth-stage biotech company. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide a unique opportunity to be a major contributor to the success of a well-positioned, well-financed growth-stage biotechnology company.

If you are interested please submit your electronic application including cover letter and CV to careers@neogene.com

No recruiters. No phone calls.

(Senior) Scientist Synthetic T Cell Biology

(Senior) Scientist Synthetic T Cell Biology

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NEW YORK

AMSTERDAM

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NEW YORK

AMSTERDAM