(Senior) Scientist Synthetic T Cell Biology

(Senior) Scientist Synthetic T Cell Biology


Neogene Therapeutics is a pre-clinical stage biotechnology company pioneering development of next-generation, fully personalized engineered T cells therapies for a broad spectrum of cancers. The Company’s engineered T cells target tumor neo-antigens, mutated proteins found in cancer cells due to cancer-associated DNA mutations, that render tumor cells vulnerable to detection by T cells. Neogene’s proprietary technology platform aims to identify TCR genes with specificity for neo-antigens from a tumor biopsy. Since every cancer expresses a unique set of neo-antigens, Neogene’s novel approach delivers a tailored set of TCR genes for each individual patient. These TCR genes are engineered into patient-derived T cells directing them towards neo-antigens in tumor cells, thereby providing a fully personalized engineered T cell therapy for cancer.

For our R&D department in Amsterdam, we are seeking a highly motivated individual to join our T cell engineering research team as a (Senior) Scientist. The individual will recognize and embrace the power of Synthetic Biology and use it to enhance the potency and clinical efficacy of neo-antigen–based T cell therapies.

Responsibilities include, but are not limited to:

  • Designing and performing experimental studies in the area of synthetic T cell biology, with a strong focus on the engineering of novel input/output circuits to enhance T cell function.
  • Driving innovation of Neogene’s pipeline, thereby paving the way for the next generation of T cell therapies.
  • Collaborating with the broader R&D team and supervising research associates and internship students.
  • Presenting obtained results in internal work discussions.
  • Keeping up to date with scientific literature, and proactively seeking out and reporting on relevant developments in the field.
  • Building and maintaining relationships with outside parties to expand Neogene’s research capabilities.
  • Documenting experimental results in electronic laboratory journal and databases.
  • Other duties as assigned.


  • PhD in Biomedical Sciences or a related field. Candidates with at least 5 years of relevant experience post PhD may be eligible for a position as Senior Scientist (at the company’s discretion).
  • A proven track-record in the field of Immunology and/or Synthetic Biology with seminal scientific contributions as exemplified by high-impact publications, patent applications, fellowships/grants and awards.
  • First-hand experience with aseptic cell culture, viral and non-viral genetic engineering (e.g. CRISPR), and multi-color flow cytometry is essential.
  • Additional training in the area of primary immune cell culture, genetic screening (vector design/construction and next-generation sequencing), and flow cytometry-based cell sorting is a plus.
  • Excellent organizational skills, a strong sense of urgency with regards to work duties and the ability to deliver results based on challenging timelines.
  • Strong verbal and written communication skills in English.
  • We are seeking a person who will lead by example and is a self-motivated team player with strong interpersonal skills.
  • Candidates must be authorized to work in The Netherlands.

We offer the opportunity to join a highly dynamic growth-stage biotech company. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide a unique opportunity to be a major contributor to the success of a well-positioned, well-financed growth-stage biotechnology company.

If you are interested please submit your electronic application including cover letter and CV to careers@neogene.com

No recruiters. No phone calls.