(Senior) Scientist, TCR Discovery Platform

(Senior) Scientist, TCR Discovery Platform


Neogene Therapeutics is a pre-clinical stage biotechnology company pioneering the development of next-generation, fully personalized engineered T cells therapies for a broad spectrum of cancers. The company’s engineered T cells target mutation-derived tumor neo-antigens thereby rendering tumor cells vulnerable to detection and destruction. Neogene’s proprietary technology platform enables the identification of TCR genes with specificity for neo-antigens from a tumor biopsy. Neogene’s novel platform delivers a tailored set of TCR genes for each individual patient thereby enabling fully personalized engineered T cell therapy for cancer.

For our Research Department in Amsterdam, we are seeking a highly motivated individual to join our TCR discovery team as a (Senior) Scientist. The individual will be responsible for designing and performing experiments to further optimize and drive the innovation of our TCR discovery platform.

Responsibilities include, but are not limited to:

  • Designing and performing experimental studies to drive the innovation of our TCR discovery platform, with a strong focus on the engineering of B cells to optimize the delivery and expression of neo-antigens for TCR identification.
  • Collaborating with the broader R&D team and supervising research associates and internship students.
  • Keeping up to date with the scientific literature, and proactively seeking out and reporting on relevant developments in the field.
  • Presenting obtained results in internal work discussions.
  • Playing an important role in building and maintaining relationships with outside parties to expand Neogene’s research capabilities.
  • Documenting experimental results in electronic laboratory journal and databases.
  • Other duties as assigned.


  • PhD in Biomedical Sciences or a related field. Candidates with at least 5 years of relevant experience post PhD may be eligible for a position as Senior Scientist (at the company’s discretion).
  • A proven track record in the field of Immunology with application in seminal scientific contributions as exemplified by high-impact publications, patent applications, fellowships/grants and awards.
  • First-hand experience with aseptic cell culture, primary immune cell culture, phenotypic and functional evaluation of immune cells, genetic engineering tools (viral or non-viral) and multi-color flow cytometry is essential
  • Additional training in the areas of genetic screening, vector design/construction, next-generation sequencing and/or flow cytometry-based cell sorting is a plus.
  • Excellent organizational skills, a strong sense of urgency with regards to work duties and the ability to deliver results based on challenging timelines.
  • Strong verbal and written communication skills in English.
  • Comfortable in a fast-paced growing company environment and able to adjust workload based upon changing priorities.
  • We are seeking a person who will lead by example and is a self-motivated team player with strong interpersonal skills and a can-do attitude.

We offer the opportunity to join a highly dynamic growth-stage biotech company. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide a unique opportunity to be a major contributor to the success of a well-positioned, well-financed growth-stage biotechnology company.

If you are interested please submit your electronic application including cover letter and CV to careers@neogene.com

No recruiters. No phone calls.