Senior Scientist, Translational Sciences

Santa Monica

We are seeking a highly motivated individual to join us as a Senior Scientist in our Translational Sciences group. Your work will support Neogene’s efforts in developing TCR-based immunotherapies for solid tumors. Under minimal supervision, you will be expected to perform experiments, organize and analyze results, and communicate and present findings in team meetings as well as provide support during regulatory filings. You will also be asked to perform other duties as required. This role will be a hands-on role reporting into a Principal Scientist.

Responsibilities include, but are not limited to:

  • Design and execute cell-based functional assays to select and characterize candidate molecules for clinical development.
  • Design and execute in vitro assays and mouse models to address basic efficacy and safety aspects of the selected candidate molecules.
  • Engineer cell lines using viral and non-viral techniques to support in vitro and in vivo assays.
  • Design assays to interrogate biospecimens from clinical trial.
  • Analyze, organize, and communicate results at different research and cross-functional meetings.
  • Participate in project teams and work cross-functionally to ensure alignment.

Requirements:

  • D. degree in immunology, cellular and/or tumor biology or a closely related field with 5-7 years of relevant postdoctoral training or industry experience preferred.
  • A strong background in cancer immunotherapy and human immunology – experience in working with engineered T cells is strongly preferred.
  • Proficient in cell culture aseptic techniques.
  • Hands-on expertise in T-cell functional characterization assays to measure in vitro cytotoxicity, proliferation, and cytokine/chemokines.
  • Hands-on expertise in addressing TCR safety (HLA-restriction, TCR specificity, alloreactivity, etc.).
  • Proficient in multi-parameter flow cytometry (panel design, sample acquisition, data processing)
  • Expertise in in vitro T-cell isolation and expansion methods.
  • Experience in viral and non-viral methods of gene transfer, including CRISPR-Cas9 mediated site-specific-integration.
  • Experience in molecular and cellular biology techniques, including but not limited to: PCR, qPCR, cloning and western blot.
  • Familiarity with syngeneic and/or xenograft mouse cancer models is desired.
  • Strong organizational and record keeping skills.
  • Excellent interpersonal, verbal and written communication skills are essential in this collaborative work environment.
  • Self-motivated and comfortable in a fast-paced company environment with minimal direction.
  • Willing to accept temporary responsibilities outside of initial job description.

We offer the opportunity to join a highly dynamic biotech start-up. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide an exciting opportunity for your career.

If you are interested please submit your electronic application including cover letter and CV to stephanie.scott@neogene.com 

No recruiters. No phone calls.

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