(Senior) Scientist, Analytical Development

Santa Monica

Neogene Therapeutics is a pre-clinical stage biotechnology company aiming to change the paradigm of treatment for solid cancers. Our mission is to provide cancer patients with T cell therapies targeting mutated proteins called neo-antigens, which are present on cancer cells as a consequence of DNA mutations. Neogene is developing novel technologies to enable the engineering of ‘designer T cells’ with neo-antigen specificities that display an optimized ability to seek and destroy cancer cells.

We are looking for an initiative-taking Scientist to join our Analytical Development (AD) team (Santa Monica, USA). The successful candidate should have strong ability in flow cytometry and cell-based assays. This role will focus on the development of cellular assays using flow cytometers and other technologies for characterizing engineered TCR T-cell therapy. AD scientists will also be key players for evaluating and implementing of technology platforms, assay transfer and assay qualification.

Responsibilities include, but are not limited to:

  • Design and develop analytical assays for characterizing T-cell therapy drug substance and drug products using flow cytometers and/or other immunoassays.
  • Author assay development reports with solid datasets to evaluate assay characteristics.
  • Perform analytical assays to provide insights for process development team.
  • Perform routine assays as a QC personnel for drug product release and characterization.
  • Drive assay life cycle, including assay optimization, transfer, and qualification.
  • Assist the establishment and operation of AD laboratories.
  • Cooperate with Neogene team in Netherland, which may involve up to 20% travel.

Requirements:

  • PhD in Immunology, Cell Biology, or related discipline with 2+ years of relevant academic or industry experience or MS with 6+ years relevant industry experience.
  • Extensive experience in executing assays and analyzing data using multi-color flow cytometry (+15 colors), such as BD Fortessa and Cytek Aurora. Data analysis using Flowjo is essential.
  • Experience in determining analytical assay characteristics and leading projects of analytical assay life cycle (qualification and/or validation).
  • First-hand experience in different cell-based assays (e.g., live cell imaging, high-content microscope, ELISA, or spatial-omics) is preferred.
  • In-depth knowledge in immunology with hands-on experience working with T cells is preferred.
  • Technical-driven, detail-oriented data analysis skills and record keeping abilities.
  • Excellent verbal, written and presentation skills for scientific studies and projects.
  • Enjoy a fast-paced, dynamic start-up company environment and able to adjust workload based upon changing priorities.

We offer the opportunity to join a highly dynamic biotech company. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide a unique opportunity to be a major contributor to the success of a well-positioned, well-financed growth-stage biotechnology company.

If you are interested, please submit your electronic application including cover letter and CV to careers@neogene.com

No recruiters. No phone calls.

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