(Senior) Scientist Synthetic TCR Libraries

Amsterdam

Neogene Therapeutics is a pre-clinical stage biotechnology company aiming to change the paradigm of treatment for solid cancers. Our mission is to provide cancer patients with T cell therapies targeting mutated proteins called neo-antigens, which are present on cancer cells as a consequence of DNA mutations. Neogene is developing novel technologies to enable the engineering of ‘designer T cells’ with neo-antigen specificities that display an optimized ability to seek and destroy cancer cells.

For our R&D department in Amsterdam, we are seeking a highly motivated individual to join our T cell engineering research team as a (Senior) Scientist. The individual will design synthetic TCR libraries to discover novel TCR candidates against recurrent viral and neo-antigens in the field of oncology, and use these TCRs to develop personalized T cell therapies.

Responsibilities include, but are not limited to:

Designing and performing experimental studies in the area of T cell Immunology, with a strong focus on the identification and genetic engineering of TCR genes to create personalized T cell therapies for cancer.
Driving innovation of Neogene’s pipeline, thereby paving the way for the next generation of T cell therapies.
Collaborating with the broader R&D team and supervising research associates and internship students.
Presenting obtained results in internal work discussions.
Keeping up to date with scientific literature, and proactively seeking out and reporting on relevant developments in the field.
Building and maintaining relationships with outside parties to expand Neogene’s research capabilities.
Documenting experimental results in electronic laboratory journal and databases.
Other duties as assigned.

Requirements:

PhD in Biomedical Sciences or a related field. Candidates with at least 5 years of relevant experience post PhD may be eligible for a position as Senior Scientist (at the company’s discretion).
A proven track-record in the field of T cell Immunology with seminal scientific contributions as exemplified by high-impact publications, patent applications, fellowships/grants and awards.
First-hand experience with primary immune cell culture, viral and/or non-viral genetic engineering (e.g. CRISPR), and multi-color flow cytometry is essential.
Additional training in the area of TCR or antibody phage display, genetic screening (vector design/construction and next-generation sequencing), and flow cytometry-based cell sorting is a plus.
Excellent organizational skills, a strong sense of urgency with regards to work duties and the ability to deliver results based on challenging timelines.
Strong verbal and written communication skills in English.
We are seeking a person who will lead by example and is a self-motivated team player with strong interpersonal skills.

We offer the opportunity to join a highly dynamic growth-stage biotech company. You can expect a collaborative environment created by a team with deep scientific expertise and an industrial track-record in T cell therapies. We value pro-active team-players who pursue their goals with dedication, endurance and a daring mindset. If you share our commitment to make a difference to patients in need, we can provide a unique opportunity to be a major contributor to the success of a well-positioned, well-financed growth-stage biotechnology company.

If you are interested please submit your electronic application including cover letter and CV to careers@neogene.com

No recruiters. No phone calls.

(Senior) Scientist Synthetic TCR Libraries

(Senior) Scientist Synthetic TCR Libraries

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NEW YORK

AMSTERDAM

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NEW YORK

AMSTERDAM